BIOEDGE
LONGEVITY SUMMIT
Where Biohacking Starts with NO
NO to one-size-fits-all protocols.
NO to optimizing a body you don’t understand.
Are you ready for what's calling you forward?
Living Well, Longer.
Experience The Summit
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ELIMINATE
Before you add anything, remove what's interfering. Chemical, digital, and behavioral noise all distort signals.
DECODE
Your body speaks in signals, not symptoms. Learn to notice what your systems are communicating.
GAIN
Optimization works after interference is eliminated and signals are decoded. The order matters.
EXECUTE
You're in it for the long term. Be patient and consistent, long enough for the body to respond.
Biological EDGE: A Practical Guide to Longevity
Available on Amazon
Biohacking Starts With NO: A Radical Guide to Longevity
Available on Amazon15 Biological Systems
Breath
Respiratory system, oxygen delivery, breathing patterns
Circulation
Heart, blood vessels, blood flow, cardiovascular health
Consciousness
Awareness, presence, thought quality, mental clarity
Defense
Immune function, inflammation, autoimmunity
Detoxification
Liver function, lymphatic drainage, elimination
Digestive
Gut health, microbiome, nutrient absorption
Emotional
Mental wellbeing, mood regulation, psychological health
Energy Production
Mitochondrial function, ATP, metabolic efficiency
Hormonal
Endocrine system, hormone balance, thyroid, adrenals
Hydration
Fluid balance, electrolytes, cellular hydration
Nervous System
Brain-body connection, neural pathways, vagal tone
Regeneration
Cellular repair, stem cells, longevity pathways
Stress Response
Fight or flight, cortisol regulation, stress adaptation
Structure & Movement
Bones, joints, connective tissue, muscles, mobility
Temperature
Heat regulation, cold tolerance, metabolic temperature
Presentations
Nathalie NiddamBioregulators & Peptides: Tap Your Body's Hidden Repair Code
Longevity educator and podcaster Nathalie Niddam explores bioregulators—tiny peptide chains that penetrate directly into cells to activate DNA repair and restore gene expression. Drawing from the groundbreaking work of Professor Khavinson's peptide theory of aging, this session demystifies how these two-to-four amino acid complexes differ from conventional peptides, why they don't need receptors to work, and how they address aging at the cellular motherboard. Niddam shares her favorite six "desert island" bioregulators and explains their role in a comprehensive longevity strategy, while navigating the evolving regulatory landscape and distinguishing between synthetic and animal-derived formulations.
Jason SonnersBreathing at Depth: How Pressure Transforms Your Cellular Recovery
Dr. Jason Sonners reveals how hyperbaric oxygen therapy fundamentally transforms cellular recovery through the physics of pressure. Drawing on 17 years of clinical experience and current PhD research in molecular biology, he demystifies how pressurized oxygen bypasses normal physiological limits to deliver therapeutic benefits unavailable through any other modality. This session breaks down the molecular mechanisms behind HBOT's effects on ATP production, stem cell mobilization, inflammation reduction, and tissue regeneration—explaining why this underutilized therapy deserves a central role in performance optimization and longevity protocols.
Andrew BustamanteCIA Secrets: Optimizing Human Energy for Peak Performance
Former CIA covert officer Andrew Bustamante reveals how intelligence operatives harness bioenergetics—the measurable science of human energy—for peak performance and influence. Drawing from classified tradecraft, Bustamante decodes the physics behind mitochondrial energy generation, body language, and energy projection. This session exposes why government agencies invest heavily in human energy research for strategic advantage and demonstrates how understanding energy density, transfer, and direction can optimize cognitive performance, persuasion, and interpersonal dynamics in high-stakes situations.
Ben AzadiFrom Sugar Burner to Fat Burner: Mastering Metabolic Freedom
Ben Azadi, founder of Keto Kamp and author of the New York Times bestseller Metabolic Freedom, reveals why most biohackers are unknowingly harming their health despite optimizing protocols. Through the concept of hormesis and practical demonstrations, Azadi explains how cold plunges, fasting, and red light therapy can become toxic stressors when your "stress bucket" is full. Drawing from his personal battle with Raynaud's syndrome and mercury poisoning, he shares the six science-backed strategies he used to raise his hormetic ceiling—including high-dose melatonin, mouth taping, and HRV tracking—enabling him to finally thrive with metabolic flexibility.
Mark YoungHacking Heart Health Through Isometric Training
Mark Young, CEO of Zona Health, challenges conventional approaches to cardiovascular health by exposing the limitations of pharmaceutical-first treatments and dietary myths surrounding hypertension. He introduces the science behind isometric exercise as a natural alternative, demonstrating how the Zona Plus device leverages static resistance training to stimulate nitric oxide production and improve blood flow. Young critiques the medical establishment's symptom-masking approach while presenting evidence-based solutions that address root causes of cardiovascular dysfunction through targeted biohacking interventions.
Dr. Melissa PetersenRewriting Your DNA: The Epigenetics of Longevity
Dr. Melissa Petersen, founder of the Human Longevity Institute, demystifies epigenetics and reveals how your DNA is not your destiny—it's your potential. Through personal storytelling and accessible science, she explains methylation, biological age testing, and the concept of the longevity escape velocity. Discover how the quality of inputs—from thoughts to foods to relationships—directly communicates with your DNA, either repressing or expressing your innate potential. With her biological age at 42 despite being chronologically 52, Dr. Petersen demonstrates that aging is optional, not inevitable.
Bernard SiegelThe Future of Longevity: Policy, Innovation, and Patient Advocacy
Bernard Siegel, Executive Director of the Healthspan Action Coalition and veteran regenerative medicine advocate, delivers a critical examination of the regulatory crossroads facing biohacking, stem cell research, and longevity medicine. Drawing on his 22-year journey from courtroom attorney to patient advocate and policy expert, Siegel explores how the current political landscape could either accelerate or extinguish innovation in peptides, psychedelics, stem cells, and emerging therapies. This session confronts the tension between regulatory oversight and scientific freedom at a pivotal moment for the health optimization movement.
Gary BreckaUnlock the Secret to Living a Longer, Fuller Life with Gary Brecka Part 1
Former insurance mortality expert Gary Brecka reveals groundbreaking insights from 22 years of predicting human lifespans to the month. Drawing from exclusive life insurance data on 370 million lives, Brecka exposes how oxygen depletion drives aging and disease through hypoxic curves. He shares the science behind modifiable risk factors that could add seven years to your healthspan, explores the hidden connections between hormone balance and oxygen transport, and explains why most health conditions aren't consequences of aging but correctable deficiencies. A data-driven approach to unlocking longevity secrets.
Gary BreckaUnlock the Secret to Living a Longer, Fuller Life with Gary Brecka Part 2
Human biologist Gary Brecka reveals how five critical genes control methylation pathways that impact everything from gut health to sleep quality and mood regulation. Drawing from his expertise in mortality modeling and functional medicine, Brecka breaks down the MTHFR, MTR, and MTRR gene mutations that affect 44% of the population, explaining how these genetic variations create neurotransmitter deficiencies often misdiagnosed as mood disorders, food allergies, or chronic gut issues. He demonstrates how simple methylated vitamin supplementation can restore proper gene function and resolve conditions like acid reflux, insomnia, and digestive problems.
Sandy MartinWhat is Biohacking?
Join bioEDGE Coach founder Sandy Martin as she moderates an insightful panel exploring the true meaning of biohacking beyond the hype. Featuring Jean Fallacara from Lifespanning and longevity enthusiast Dave Pascoe, this discussion reveals diverse approaches to optimization—from brain-first strategies to supplement cycling. Discover practical insights on starting your biohacking journey, the importance of eliminating toxins before adding supplements, and why happiness might be the ultimate biohack. Perfect for beginners and experienced biohackers seeking evidence-based perspectives on health optimization.
How Electromagnetic Fields Support Your Body's Natural Healing Rhythms
Discover how combining PEMF therapy with sound frequencies can restore cellular resonance, supporting everything from mitochondrial function to nervous system regulation in a practical home-use system.
How Light and Sound Training Can Sharpen Your Brain's Recovery Mode
Your brain cycles through distinct electrical states every day, and how smoothly it transitions between them affects everything from sleep quality to cognitive sharpness. Brainwave entrainment, paired with light therapy, offers a structured way to train that flexibility.
Metabolic Flexibility: Your Body's Natural Ability to Switch Between Fuel Sources
Modern eating patterns have locked most people into glucose-burning mode, but your cells remember how to be metabolically flexible. Strategic ketogenic nutrition and fasting can reactivate your body's natural ability to switch between fuel sources.
Seven Inputs Your Brain Expects Every Day, Ordered by How Fast You'd Die Without Them
Your brain consumes 20% of your oxygen and calories despite being 2% of your body weight. Giving it the right inputs, in the right order, may be the most overlooked strategy in health optimization.
Telomere Length: The Cellular Clock You Can Actually Influence
Scientists have discovered how to rebuild your cells' protective caps—telomeres—that shorten with age. New research shows telomerase activation can reduce inflammation by 62% and measurably reverse cellular aging markers.
The Gut-Brain Axis: Your Body's Hidden Highway to Mental Clarity and Digestive Calm
Recent research reveals how specific wavelengths of red and near-infrared light can enhance the gut-brain axis by boosting mitochondrial ATP production, supporting both mental clarity and digestive comfort through targeted cellular energy optimization.
The NAD+ Optimization Blueprint: Why Testing Beats Guessing for Cellular Energy
Discover why measuring intracellular NAD+ levels transforms guesswork into precision optimization, helping you maintain cellular energy and vitality decades longer.
What Birth Tissues Reveal About Your Body's Built-In Repair System
Your body already contains the machinery for regeneration. Researchers are now exploring how perinatal birth tissues, rich in growth factors, extracellular vesicles, and matrix, may hold clues to restoring the repair capacity that declines with age.
Why Traditional Fermentation Makes Protein More Powerful for Longevity
Ancient fermentation unlocks 30% more protein absorption while creating longevity compounds modern processing destroys. Discover why grass-fed beef transformed through time-honored methods outperforms supplements.
Why Your Biohacking Stack Isn't Working
Most biohackers fail because they optimize before eliminating what's sabotaging their biology. Discover why removing interference beats adding interventions—and how to finally make your health stack work.
Why Your Hormones Hold the Key to Thriving Through Midlife
Discover how adaptogenic herbs and alkaline nutrition can transform your midlife experience. Dr. Anna Cabeca's functional approach helps women navigate hormonal shifts with energy, clarity, and confidence.
Your Body Already Knows How to Repair Itself. Here's How to Give It More Resources.
Stem cell availability declines with age, leaving tissues that once healed quickly struggling to repair. Discover how specific botanicals can increase circulating stem cells by up to 80%, restoring your body's natural renewal capacity.
APOE2 Protects Neurons from DNA Damage and Aging
APOE2 protects neurons by enhancing DNA repair capacity and preventing cellular senescence, independent of its canonical lipid-transport function. This mechanism offers a distinct pathway for neuronal longevity and suggests therapeutic targets for neurodegenerative disease prevention.
- APOE2 enhances DNA repair and reduces cellular senescence in neurons
- Protection operates through genomic integrity, not lipid metabolism alone
- Mechanism identifies therapeutic target for Alzheimer's disease prevention
Longevity Significance
The identification of APOE2's role in maintaining genomic integrity shifts understanding of how genetic variants influence brain aging. Rather than solely managing lipid transport, this variant actively supports the neuron's ability to recognize and correct DNA damage—a fundamental process that determines whether cells remain functional or enter senescence. This distinction matters because it reveals actionable biology: interventions that strengthen DNA surveillance and repair mechanisms, whether through genetic, pharmacological, or behavioral pathways, may slow neurodegeneration at the cellular level. The implication extends beyond Alzheimer's; preserving the integrity of the genome is foundational to extending cognitive function across the human lifespan.
Current Clinical Trials of Alzheimer’s Drugs
Clinical trials for Alzheimer's disease have expanded significantly, with 158 drugs across 192 trials currently under investigation. The pipeline reflects a strategic shift toward multi-target approaches, particularly inflammation and immune dysfunction alongside established amyloid and tau pathways, reflecting recognition that cognitive decline involves multiple biological mechanisms requiring coordinated intervention.
- 158 drugs in 192 trials; 35% increase in trials over past decade
- Pipeline shifted from amyloid-only to inflammation, tau, and immune dysfunction targets
- 75% of drugs target disease progression; 35% are repurposed from other indications
Longevity Significance
The expansion and diversification of Alzheimer's trials signal recognition that cognitive resilience depends on multiple intersecting systems—inflammatory regulation, immune function, neurotransmitter signaling, and protein clearance all contribute to the disease trajectory. Rather than relying on single-mechanism interventions, the field is moving toward combination approaches that address how these systems interact. This mirrors the broader clinical reality: preventing cognitive decline requires identifying which specific mechanisms are interfering with normal brain function in each individual, then strategically supporting the systems that maintain neural health and communication. The increasing focus on early intervention (asymptomatic and mild cognitive impairment stages) suggests that therapeutic windows exist before irreversible damage accumulates, making early detection and system-level support increasingly relevant to longevity strategy.
Sironax receives FDA fast track status for neuroprotective SARM1 inhibitor
Sironax's SIR2501, a first-in-class allosteric SARM1 inhibitor, received FDA Fast Track designation for chemotherapy-induced peripheral neuropathy, a serious complication of cancer treatment with limited therapeutic options. The mechanism preserves nerve function by maintaining SARM1 in an inactive state, with Phase 1b/2 trials underway in CIPN and ALS.
- First-in-class allosteric SARM1 inhibitor addresses unmet CIPN treatment need
- FDA Fast Track status enables accelerated development and regulatory review
- Preclinical data show neuroprotection without adverse effects of orthosteric inhibitors
Longevity Significance
Chemotherapy-induced peripheral neuropathy represents a significant barrier to cancer survival, as nerve damage often forces treatment discontinuation or dose reduction. SARM1 inhibition offers a mechanism to preserve neural integrity during cytotoxic therapy—protecting the nervous system's signaling capacity and regenerative potential without compromising cancer treatment efficacy. This approach aligns with the principle of sustaining function across multiple systems rather than simply managing symptoms, extending both lifespan and healthspan in cancer survivors.