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Biohacking Starts With NO

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Mental and Cognitive Health

Mental and Cognitive Health Library

Every article, presentation, spotlight, and news item we've tagged to Mental and Cognitive Health.

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Showing 121–126 of 126

Longevity.TechnologyMar 26, 2026

Cognito and Ochsner launch brain health collaboratory

Cognito Therapeutics and Ochsner Health have established a regional platform to evaluate Spectris, a non-invasive device that uses synchronized light and sound to stimulate gamma-frequency brain activity, alongside clinical infrastructure to assess its effectiveness in cognitive decline and Alzheimer's disease. The collaboratory will generate real-world data on treatment response, cost-effectiveness, and scalability across diverse populations.

Nature AgingMay 12, 2026

Somatic variants in microglia-like cells linked to Alzheimer’s disease pathology

Somatic mutations accumulating in microglia—brain immune cells—correlate with Alzheimer's disease pathology and cognitive decline. These acquired genetic variants, distinct from inherited risk factors, represent a previously underappreciated mechanism driving neurodegeneration and suggest new intervention points before symptomatic disease emerges.

Nature AgingMay 12, 2026

Brain endothelial cell-derived extracellular vesicles (c-BEEVs) as a promising biomarker for brain vascular pathology and cognitive decline

Brain endothelial cell-derived extracellular vesicles (c-BEEVs) detected in cerebrospinal fluid serve as a measurable biomarker for vascular dysfunction affecting the brain and cognitive decline. This discovery enables earlier detection of neurovascular pathology before symptomatic cognitive loss.

Longevity.TechnologyApr 14, 2026

AI sharpens Alzheimer’s PET readouts

An artificial intelligence framework called interpretable adversarial decomposition learning (ADL) improves the clinical utility of Alzheimer's PET scans by filtering noise from disease signal, producing an ADAD score that correlates more closely with cognitive decline and neurodegeneration than traditional scoring methods. This advancement addresses a persistent gap between imaging findings and actual patient outcomes.

LifeSpan.ioApr 28, 2026

Obesity’s Effects on the Immune System May Linger for Years

T cells retain pro-inflammatory characteristics long after weight loss, perpetuating immune dysregulation in previously obese individuals. This 'obesity memory' may persist for years in humans despite normalization of body mass, suggesting that metabolic recovery and immune recovery operate on different timelines.

Nature AgingApr 3, 2026

Neuronal APOE4-induced early hippocampal network hyperexcitability in Alzheimer’s disease pathogenesis

Young mice carrying the APOE4 gene variant show excessive electrical activity in the hippocampus before cognitive decline becomes apparent, a pattern driven by neuronal APOE4 expression itself. This early hyperexcitability represents a tractable target for intervention, as it can be reversed through modulation of the Nell2 pathway.